Well, first of all, happy Valentine's day for those who care about that day. As a present for you all, Focus, the official distributor, has made a guide to make the game work on the newly released Windows Vista:

"Install and run PCM2006 on Windows Vista :

1. Please insert the PCM2006 CD and click Install button.
2. Wait while Windows Vista is checking the game installation (SETUP.EXE file).
3. If you cannot install the Game Center, please click Cancel.
4. Do not run PCM2006.
5. Please download and install the 1.0.0.8 update for PCM2006 http://www.cyanide-studio.com/forums/viewtopic.php?t=49305
6. Open Computer.
7. Open C:\Program Files\Cyanide\Pro Cycling Manager - Season 2006 folder.
8. Right mouse click on PCM (PCM.EXE) file and click Run as administrator.
9. Restart the computer.
10. Click the following link to download the latest protection drivers update http://www.star-force.com/support/sfdrvup.zip
11. Open SFDRVUP.ZIP and run SFDRVUP.EXE.
12. Click OK to restart the computer.
13. Run PCM2006 by double-clicking the shortcut on the Desktop.

To get the latest Game Center version, click http://gamecenter.cyanide-studio.com/?rub=download&product=0

About the online gaming, if you cannot see the online games, please press ALT+TAB keys to display the Desktop.
If PCM2006 is locked by the Windows Firewall, please unlock it.
Press again ALT+TAB to go back to PCM2006."